Pbx4, a new Pbx family member on mouse chromosome 8, is expressed during spermatogenesis

K Wagner; A Mincheva; B Korn; P Lichter; H Pöpperl

doi:10.1016/s0925-4773(01)00349-5

Pbx4, a new Pbx family member on mouse chromosome 8, is expressed during spermatogenesis

Mech Dev. 2001 May;103(1-2):127-31. doi: 10.1016/s0925-4773(01)00349-5.

Authors

K Wagner¹, A Mincheva, B Korn, P Lichter, H Pöpperl

Affiliation

¹ Abteilung Pathogenitätsmechanismen, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.

PMID: 11335119
DOI: 10.1016/s0925-4773(01)00349-5

Abstract

Members of the Pbx family are involved in a diverse range of developmental processes including axial patterning and organogenesis. Pbx functions are in part mediated by the interaction of Pbx proteins with members of the Hox and Meis/Prep families. We have identified a fourth mammalian Pbx family member. Pbx4 in the mouse and PBX4 in humans are located on chromosome 8 and chromosome 19, respectively. Pbx4 expression is confined to the testis, especially to spermatocytes in the pachytene stage of the first meiotic prophase.

MeSH terms

Amino Acid Sequence
Animals
Blotting, Northern
Chromosome Mapping
Chromosomes, Human, Pair 19
DNA Primers
DNA, Complementary / metabolism
DNA-Binding Proteins / biosynthesis*
DNA-Binding Proteins / genetics*
Humans
Immunohistochemistry
In Situ Hybridization
In Situ Hybridization, Fluorescence
Male
Meiosis
Mice
Models, Genetic
Molecular Sequence Data
Protein Binding
Reverse Transcriptase Polymerase Chain Reaction
Sequence Homology, Amino Acid
Spermatogenesis*
Testis / metabolism
Tissue Distribution
Transcription Factors

Substances

DNA Primers
DNA, Complementary
DNA-Binding Proteins
PBX4 protein, human
Pbx4 protein, mouse
Transcription Factors