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Year | Number of Results |
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PubMed (OMIM) for id: 200734
7 results
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SPRED2 loss-of-function causes a recessive Noonan syndrome-like phenotype.
Am J Hum Genet. 2021 Nov 4;108(11):2112-2129. doi: 10.1016/j.ajhg.2021.09.007. Epub 2021 Oct 8.
Am J Hum Genet. 2021.
PMID: 34626534
Free PMC article.
OCD-like behavior is caused by dysfunction of thalamo-amygdala circuits and upregulated TrkB/ERK-MAPK signaling as a result of SPRED2 deficiency.
Ullrich M, Weber M, Post AM, Popp S, Grein J, Zechner M, Guerrero González H, Kreis A, Schmitt AG, Üçeyler N, Lesch KP, Schuh K.
Ullrich M, et al.
Mol Psychiatry. 2018 Feb;23(2):444-458. doi: 10.1038/mp.2016.232. Epub 2017 Jan 10.
Mol Psychiatry. 2018.
PMID: 28070119
Free PMC article.
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Identification of SPRED2 (sprouty-related protein with EVH1 domain 2) as a negative regulator of the hypothalamic-pituitary-adrenal axis.
Ullrich M, Bundschu K, Benz PM, Abesser M, Freudinger R, Fischer T, Ullrich J, Renné T, Walter U, Schuh K.
Ullrich M, et al.
J Biol Chem. 2011 Mar 18;286(11):9477-88. doi: 10.1074/jbc.M110.171306. Epub 2011 Jan 3.
J Biol Chem. 2011.
PMID: 21199868
Free PMC article.
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Gene disruption of Spred-2 causes dwarfism.
Bundschu K, Knobeloch KP, Ullrich M, Schinke T, Amling M, Engelhardt CM, Renné T, Walter U, Schuh K.
Bundschu K, et al.
J Biol Chem. 2005 Aug 5;280(31):28572-80. doi: 10.1074/jbc.M503640200. Epub 2005 Jun 9.
J Biol Chem. 2005.
PMID: 15946934
Free article.
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Spred-1 negatively regulates interleukin-3-mediated ERK/mitogen-activated protein (MAP) kinase activation in hematopoietic cells.
Nonami A, Kato R, Taniguchi K, Yoshiga D, Taketomi T, Fukuyama S, Harada M, Sasaki A, Yoshimura A.
Nonami A, et al.
J Biol Chem. 2004 Dec 10;279(50):52543-51. doi: 10.1074/jbc.M405189200. Epub 2004 Sep 30.
J Biol Chem. 2004.
PMID: 15465815
Free article.
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Molecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation.
Kato R, Nonami A, Taketomi T, Wakioka T, Kuroiwa A, Matsuda Y, Yoshimura A.
Kato R, et al.
Biochem Biophys Res Commun. 2003 Mar 21;302(4):767-72. doi: 10.1016/s0006-291x(03)00259-6.
Biochem Biophys Res Commun. 2003.
PMID: 12646235
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Spred is a Sprouty-related suppressor of Ras signalling.
Wakioka T, Sasaki A, Kato R, Shouda T, Matsumoto A, Miyoshi K, Tsuneoka M, Komiya S, Baron R, Yoshimura A.
Wakioka T, et al.
Nature. 2001 Aug 9;412(6847):647-51. doi: 10.1038/35088082.
Nature. 2001.
PMID: 11493923
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