PubMed for id: 432940

Year	Number of Results
1999	1
2000	4
2001	1
2002	2
2004	1
2005	3
2011	1
2013	1
2014	1
2016	1
2017	3
2018	1
2020	3
2021	3
2023	3
2024	0

1

OTULIN protects the intestinal epithelium from apoptosis during inflammation and infection.

Verboom L, Anderson CJ, Jans M, Petta I, Blancke G, Martens A, Sze M, Hochepied T, Ravichandran KS, Vereecke L, van Loo G. Verboom L, et al. Cell Death Dis. 2023 Aug 19;14(8):534. doi: 10.1038/s41419-023-06058-7. Cell Death Dis. 2023. PMID: 37598207 Free PMC article.

2

Linear ubiquitination of cytosolic Salmonella Typhimurium activates NF-κB and restricts bacterial proliferation.

van Wijk SJL, Fricke F, Herhaus L, Gupta J, Hötte K, Pampaloni F, Grumati P, Kaulich M, Sou YS, Komatsu M, Greten FR, Fulda S, Heilemann M, Dikic I. van Wijk SJL, et al. Nat Microbiol. 2017 May 8;2:17066. doi: 10.1038/nmicrobiol.2017.66. Nat Microbiol. 2017. PMID: 28481361

3

OTULIN protects the liver against cell death, inflammation, fibrosis, and cancer.

Damgaard RB, Jolin HE, Allison MED, Davies SE, Titheradge HL, McKenzie ANJ, Komander D. Damgaard RB, et al. Cell Death Differ. 2020 May;27(5):1457-1474. doi: 10.1038/s41418-020-0532-1. Epub 2020 Mar 30. Cell Death Differ. 2020. PMID: 32231246 Free PMC article.

4

A genetic screen for mutations that affect cranial nerve development in the mouse.

Mar L, Rivkin E, Kim DY, Yu JY, Cordes SP. Mar L, et al. J Neurosci. 2005 Dec 14;25(50):11787-95. doi: 10.1523/JNEUROSCI.3813-05.2005. J Neurosci. 2005. PMID: 16354937 Free PMC article.

5

Myeloid OTULIN deficiency couples RIPK3-dependent cell death to Nlrp3 inflammasome activation and IL-1β secretion.

Doglio MG, Verboom L, Ruilova Sosoranga E, Frising UC, Asaoka T, Gansemans Y, Van Nieuwerburgh F, van Loo G, Wullaert A. Doglio MG, et al. Sci Immunol. 2023 Nov 24;8(89):eadf4404. doi: 10.1126/sciimmunol.adf4404. Epub 2023 Nov 24. Sci Immunol. 2023. PMID: 38000038

6

OTULIN inhibits RIPK1-mediated keratinocyte necroptosis to prevent skin inflammation in mice.

Schünke H, Göbel U, Dikic I, Pasparakis M. Schünke H, et al. Nat Commun. 2021 Oct 8;12(1):5912. doi: 10.1038/s41467-021-25945-1. Nat Commun. 2021. PMID: 34625557 Free PMC article.

7

OTULIN limits cell death and inflammation by deubiquitinating LUBAC.

Heger K, Wickliffe KE, Ndoja A, Zhang J, Murthy A, Dugger DL, Maltzman A, de Sousa E Melo F, Hung J, Zeng Y, Verschueren E, Kirkpatrick DS, Vucic D, Lee WP, Roose-Girma M, Newman RJ, Warming S, Hsiao YC, Kőműves LG, Webster JD, Newton K, Dixit VM. Heger K, et al. Nature. 2018 Jul;559(7712):120-124. doi: 10.1038/s41586-018-0256-2. Epub 2018 Jun 27. Nature. 2018. PMID: 29950720

8

OTULIN Prevents Liver Inflammation and Hepatocellular Carcinoma by Inhibiting FADD- and RIPK1 Kinase-Mediated Hepatocyte Apoptosis.

Verboom L, Martens A, Priem D, Hoste E, Sze M, Vikkula H, Van Hove L, Voet S, Roels J, Maelfait J, Bongiovanni L, de Bruin A, Scott CL, Saeys Y, Pasparakis M, Bertrand MJM, van Loo G. Verboom L, et al. Cell Rep. 2020 Feb 18;30(7):2237-2247.e6. doi: 10.1016/j.celrep.2020.01.028. Cell Rep. 2020. PMID: 32075762 Free article.

9

The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis.

Rivkin E, Almeida SM, Ceccarelli DF, Juang YC, MacLean TA, Srikumar T, Huang H, Dunham WH, Fukumura R, Xie G, Gondo Y, Raught B, Gingras AC, Sicheri F, Cordes SP. Rivkin E, et al. Nature. 2013 Jun 20;498(7454):318-24. doi: 10.1038/nature12296. Epub 2013 May 24. Nature. 2013. PMID: 23708998 Free PMC article.

10

Suppression of LUBAC-mediated linear ubiquitination by a specific interaction between LUBAC and the deubiquitinases CYLD and OTULIN.

Takiuchi T, Nakagawa T, Tamiya H, Fujita H, Sasaki Y, Saeki Y, Takeda H, Sawasaki T, Buchberger A, Kimura T, Iwai K. Takiuchi T, et al. Genes Cells. 2014 Mar;19(3):254-72. doi: 10.1111/gtc.12128. Epub 2014 Jan 26. Genes Cells. 2014. PMID: 24461064 Free article.

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