PubMed for id: 319757

Year	Number of Results
1996	1
1997	1
1998	4
1999	6
2000	5
2001	7
2002	8
2003	6
2004	12
2005	14
2006	22
2007	13
2008	27
2009	38
2010	24
2011	28
2012	40
2013	34
2014	21
2015	31
2016	31
2017	30
2018	27
2019	26
2020	18
2021	13
2022	13
2023	5
2024	0

1

Hedgehog signal activates AMPK via Smoothened to promote autophagy and lipid degradation in hepatocytes.

Yao Y, Li T, Yu T, Yang X, Wang Y, Cai J, Cheng SY, Liu C, Yue S. Yao Y, et al. Biochem Cell Biol. 2023 Aug 1;101(4):284-293. doi: 10.1139/bcb-2022-0345. Epub 2023 Feb 23. Biochem Cell Biol. 2023. PMID: 36821837 Free article.

2

Aging reduces liver resiliency by dysregulating Hedgehog signaling.

Maeso-Díaz R, Dalton GD, Oh S, Du K, Tang L, Chen T, Dutta RK, Hartman JH, Meyer JN, Diehl AM. Maeso-Díaz R, et al. Aging Cell. 2022 Feb;21(2):e13530. doi: 10.1111/acel.13530. Epub 2022 Jan 4. Aging Cell. 2022. PMID: 34984806 Free PMC article.

3

Dual activation of Shh and Notch signaling induces dramatic enlargement of neocortical surface area.

Ohtsuka T, Kageyama R. Ohtsuka T, et al. Neurosci Res. 2022 Mar;176:18-30. doi: 10.1016/j.neures.2021.09.006. Epub 2021 Sep 30. Neurosci Res. 2022. PMID: 34600946

4

Hepatocyte activity of the cholesterol sensor smoothened regulates cholesterol and bile acid homeostasis in mice.

Dalton GD, Oh SH, Tang L, Zhang S, Brown AL, Varadharajan V, Baleanu-Gogonea C, Gogonea V, Pathak P, Brown JM, Diehl AM. Dalton GD, et al. iScience. 2021 Sep 4;24(9):103089. doi: 10.1016/j.isci.2021.103089. eCollection 2021 Sep 24. iScience. 2021. PMID: 34568800 Free PMC article.

5

Smoothened stimulation by membrane sterols drives Hedgehog pathway activity.

Deshpande I, Liang J, Hedeen D, Roberts KJ, Zhang Y, Ha B, Latorraca NR, Faust B, Dror RO, Beachy PA, Myers BR, Manglik A. Deshpande I, et al. Nature. 2019 Jul;571(7764):284-288. doi: 10.1038/s41586-019-1355-4. Epub 2019 Jul 1. Nature. 2019. PMID: 31263273 Free PMC article.

6

Human SMOOTHENED inhibits human immunodeficiency virus type 1 infection.

Yoshida T, Hamano A, Ueda A, Takeuchi H, Yamaoka S. Yoshida T, et al. Biochem Biophys Res Commun. 2017 Nov 4;493(1):132-138. doi: 10.1016/j.bbrc.2017.09.063. Epub 2017 Sep 14. Biochem Biophys Res Commun. 2017. PMID: 28917838

7

Constitutive Activation of Smoothened in the Renal Collecting Ducts Leads to Renal Hypoplasia, Hydronephrosis, and Hydroureter.

Gupta DP, Hwang JW, Cho ES, Kim W, Song CH, Chai OH. Gupta DP, et al. Cells Tissues Organs. 2017;204(1):38-48. doi: 10.1159/000464460. Epub 2017 Jun 1. Cells Tissues Organs. 2017. PMID: 28564646

8

Tetramethylpyrazine attenuates sinusoidal angiogenesis via inhibition of hedgehog signaling in liver fibrosis.

Zhao S, Zhang Z, Yao Z, Shao J, Chen A, Zhang F, Zheng S. Zhao S, et al. IUBMB Life. 2017 Feb;69(2):115-127. doi: 10.1002/iub.1598. Epub 2017 Jan 23. IUBMB Life. 2017. PMID: 28112475 Free article.

9

Hedgehog signaling is a potent regulator of liver lipid metabolism and reveals a GLI-code associated with steatosis.

Matz-Soja M, Rennert C, Schönefeld K, Aleithe S, Boettger J, Schmidt-Heck W, Weiss TS, Hovhannisyan A, Zellmer S, Klöting N, Schulz A, Kratzsch J, Guthke R, Gebhardt R. Matz-Soja M, et al. Elife. 2016 May 17;5:e13308. doi: 10.7554/eLife.13308. Elife. 2016. PMID: 27185526 Free PMC article.

10

Astrocyte-Dependent Vulnerability to Excitotoxicity in Spermine Oxidase-Overexpressing Mouse.

Cervetto C, Vergani L, Passalacqua M, Ragazzoni M, Venturini A, Cecconi F, Berretta N, Mercuri N, D'Amelio M, Maura G, Mariottini P, Voci A, Marcoli M, Cervelli M. Cervetto C, et al. Neuromolecular Med. 2016 Mar;18(1):50-68. doi: 10.1007/s12017-015-8377-3. Epub 2015 Nov 3. Neuromolecular Med. 2016. PMID: 26530396

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