PubMed for id: 22909

Year	Number of Results
1993	1
1999	1
2002	1
2004	2
2005	1
2006	2
2007	1
2010	7
2011	2
2012	3
2013	2
2014	7
2015	5
2016	3
2017	4
2018	1
2019	3
2020	5
2021	6
2022	5
2023	1
2024	1

1

FAN1 removes triplet repeat extrusions via a PCNA- and RFC-dependent mechanism.

Phadte AS, Bhatia M, Ebert H, Abdullah H, Elrazaq EA, Komolov KE, Pluciennik A. Phadte AS, et al. Proc Natl Acad Sci U S A. 2023 Aug 15;120(33):e2302103120. doi: 10.1073/pnas.2302103120. Epub 2023 Aug 7. Proc Natl Acad Sci U S A. 2023. PMID: 37549289 Free PMC article.

2

Persistent DNA damage underlies tubular cell polyploidization and progression to chronic kidney disease in kidneys deficient in the DNA repair protein FAN1.

Airik M, Phua YL, Huynh AB, McCourt BT, Rush BM, Tan RJ, Vockley J, Murray SL, Dorman A, Conlon PJ, Airik R. Airik M, et al. Kidney Int. 2022 Nov;102(5):1042-1056. doi: 10.1016/j.kint.2022.07.003. Epub 2022 Aug 2. Kidney Int. 2022. PMID: 35931300 Free PMC article.

3

Exome sequencing of individuals with Huntington's disease implicates FAN1 nuclease activity in slowing CAG expansion and disease onset.

McAllister B, Donaldson J, Binda CS, Powell S, Chughtai U, Edwards G, Stone J, Lobanov S, Elliston L, Schuhmacher LN, Rees E, Menzies G, Ciosi M, Maxwell A, Chao MJ, Hong EP, Lucente D, Wheeler V, Lee JM, MacDonald ME, Long JD, Aylward EH, Landwehrmeyer GB, Rosser AE; REGISTRY Investigators of the European Huntington’s disease network; Paulsen JS; PREDICT-HD Investigators of the Huntington Study Group; Williams NM, Gusella JF, Monckton DG, Allen ND, Holmans P, Jones L, Massey TH. McAllister B, et al. Nat Neurosci. 2022 Apr;25(4):446-457. doi: 10.1038/s41593-022-01033-5. Epub 2022 Apr 4. Nat Neurosci. 2022. PMID: 35379994 Free PMC article.

4

FAN1 exo- not endo-nuclease pausing on disease-associated slipped-DNA repeats: A mechanism of repeat instability.

Deshmukh AL, Caron MC, Mohiuddin M, Lanni S, Panigrahi GB, Khan M, Engchuan W, Shum N, Faruqui A, Wang P, Yuen RKC, Nakamori M, Nakatani K, Masson JY, Pearson CE. Deshmukh AL, et al. Cell Rep. 2021 Dec 7;37(10):110078. doi: 10.1016/j.celrep.2021.110078. Cell Rep. 2021. PMID: 34879276 Free article.

5

FAN1, a DNA Repair Nuclease, as a Modifier of Repeat Expansion Disorders.

Deshmukh AL, Porro A, Mohiuddin M, Lanni S, Panigrahi GB, Caron MC, Masson JY, Sartori AA, Pearson CE. Deshmukh AL, et al. J Huntingtons Dis. 2021;10(1):95-122. doi: 10.3233/JHD-200448. J Huntingtons Dis. 2021. PMID: 33579867 Free PMC article. Review.

6

Genetic and Functional Analyses Point to FAN1 as the Source of Multiple Huntington Disease Modifier Effects.

Kim KH, Hong EP, Shin JW, Chao MJ, Loupe J, Gillis T, Mysore JS, Holmans P, Jones L, Orth M, Monckton DG, Long JD, Kwak S, Lee R, Gusella JF, MacDonald ME, Lee JM. Kim KH, et al. Am J Hum Genet. 2020 Jul 2;107(1):96-110. doi: 10.1016/j.ajhg.2020.05.012. Epub 2020 Jun 25. Am J Hum Genet. 2020. PMID: 32589923 Free PMC article.

7

Common variants in FAN1, located in 15q13.3, confer risk for schizophrenia and bipolar disorder in Han Chinese.

Jian X, Chen J, Li Z, Fahira A, Shao W, Zhou J, Wang K, Wen Y, Zhang J, Yang Q, Pan D, Wang Z, Shi Y. Jian X, et al. Prog Neuropsychopharmacol Biol Psychiatry. 2020 Dec 20;103:109973. doi: 10.1016/j.pnpbp.2020.109973. Epub 2020 May 22. Prog Neuropsychopharmacol Biol Psychiatry. 2020. PMID: 32450113

8

Variation in DNA Repair System Gene as an Additional Modifier of Age at Onset in Spinocerebellar Ataxia Type 3/Machado-Joseph Disease.

Mergener R, Furtado GV, de Mattos EP, Leotti VB, Jardim LB, Saraiva-Pereira ML. Mergener R, et al. Neuromolecular Med. 2020 Mar;22(1):133-138. doi: 10.1007/s12017-019-08572-4. Epub 2019 Oct 5. Neuromolecular Med. 2020. PMID: 31587151

9

Prevalence of Pathogenic Variants of FAN1 in More Than 5000 Patients Assessed for Genetic Predisposition to Colorectal, Breast, Ovarian, or Other Cancers.

Fievet A, Mouret-Fourme E, Colas C, de Pauw A, Stoppa-Lyonnet D, Buecher B. Fievet A, et al. Gastroenterology. 2019 May;156(6):1919-1920. doi: 10.1053/j.gastro.2019.01.003. Epub 2019 Jan 9. Gastroenterology. 2019. PMID: 30639725 No abstract available.

10

Importance of homo-dimerization of Fanconi-associated nuclease 1 in DNA flap cleavage.

Rao T, Longerich S, Zhao W, Aihara H, Sung P, Xiong Y. Rao T, et al. DNA Repair (Amst). 2018 Apr;64:53-58. doi: 10.1016/j.dnarep.2018.02.007. Epub 2018 Feb 21. DNA Repair (Amst). 2018. PMID: 29518739 Free PMC article.

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