Abstract
We have cloned and characterized the coding sequence of the human HAND2 basic helix-loop-helix transcription factor. The amino acid sequence includes an amino-terminal polyalanine repeat which is precisely conserved in the rat HAND2 gene. Northern analysis indicates that the HAND2 transcript is 2.3 kb in length and strongly expressed in the human heart.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Base Sequence
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Basic Helix-Loop-Helix Transcription Factors
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Chromosome Mapping
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Chromosomes, Human, Pair 4 / genetics
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Cloning, Molecular
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DNA / chemistry
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DNA / genetics
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DNA, Complementary / chemistry
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DNA, Complementary / genetics
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DNA-Binding Proteins / genetics*
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Gene Expression
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Genes / genetics*
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Humans
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Molecular Sequence Data
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RNA, Messenger / genetics
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RNA, Messenger / metabolism
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Sequence Alignment
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Sequence Analysis, DNA
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Sequence Homology, Amino Acid
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Sequence Homology, Nucleic Acid
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Tissue Distribution
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Transcription Factors / genetics*
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Zebrafish Proteins
Substances
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Basic Helix-Loop-Helix Transcription Factors
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DNA, Complementary
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DNA-Binding Proteins
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HAND2 protein, human
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RNA, Messenger
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Transcription Factors
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Zebrafish Proteins
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hand2 protein, zebrafish
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DNA
Associated data
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GENBANK/AF087940
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GENBANK/AF087941