Molecular cloning and expression of human chondroitin 6-sulfotransferase

Biochim Biophys Acta. 1998 Jul 30;1399(1):57-61. doi: 10.1016/s0167-4781(98)00089-x.

Abstract

Using cDNA of chick chondroitin 6-sulfotransferase (C6ST), human C6ST cDNA has been isolated. The amino acid sequence of human C6ST displayed 74% identity to chick C6ST. The major difference in amino acid sequence between chick C6ST and human C6ST was the presence of a unique hydrophilic domain in human C6ST. A 7.8-kb message of C6ST was expressed ubiquitously in various human adult tissues, indicating a rather diverse function of C6ST.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Brain / metabolism
  • COS Cells
  • Carbohydrate Sulfotransferases
  • Cloning, Molecular
  • DNA, Complementary / chemistry
  • DNA, Complementary / isolation & purification
  • Gene Expression
  • Humans
  • Molecular Sequence Data
  • Sequence Alignment
  • Sulfotransferases / biosynthesis
  • Sulfotransferases / chemistry
  • Sulfotransferases / genetics*
  • Transfection

Substances

  • DNA, Complementary
  • Sulfotransferases

Associated data

  • GENBANK/AB012192