Abstract
Using cDNA of chick chondroitin 6-sulfotransferase (C6ST), human C6ST cDNA has been isolated. The amino acid sequence of human C6ST displayed 74% identity to chick C6ST. The major difference in amino acid sequence between chick C6ST and human C6ST was the presence of a unique hydrophilic domain in human C6ST. A 7.8-kb message of C6ST was expressed ubiquitously in various human adult tissues, indicating a rather diverse function of C6ST.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Brain / metabolism
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COS Cells
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Carbohydrate Sulfotransferases
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Cloning, Molecular
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DNA, Complementary / chemistry
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DNA, Complementary / isolation & purification
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Gene Expression
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Humans
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Molecular Sequence Data
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Sequence Alignment
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Sulfotransferases / biosynthesis
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Sulfotransferases / chemistry
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Sulfotransferases / genetics*
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Transfection
Substances
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DNA, Complementary
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Sulfotransferases