Genomic organization and mapping of the human acti...[J Hum Genet. 1998]

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1: J Hum Genet. 1998;43(2):132-4.Links

Genomic organization and mapping of the human activin receptor type IIB (hActR-IIB) gene.

Ishikawa S, Kai M, Murata Y, Tamari M, Daigo Y, Murano T, Ogawa M, Nakamura Y.

Laboratory of Molecular Medicine, University of Tokyo, Japan.

Activins, members of a family of proteins that includes transforming growth factor-beta (TGF-beta), are gonadal polypeptide hormones that stimulate secretion of follicle-stimulating hormone (FSH). During large-scale sequencing analysis of a 1.2-Mb fragment of human genomic DNA on 3p22-p21.3, we found the gene encoding activin receptor type IIB (hActR-IIB). Comparison of its reported cDNA sequence with this genomic sequence showed that the hActR-IIB gene consists of 11 exons and spans about 30 kb of genomic DNA.

PMID: 9621519 [PubMed - indexed for MEDLINE]

Assignment of ACVR2 and ACVR2B the human activin receptor type II and IIB genes to chromosome bands 2q22.2-->q23.3 and 3p22 and the human follistatin gene (FST) to chromosome 5q11.2 by FISH. [Cytogenet Cell Genet. 1999]
Expression of type II activin receptor genes during differentiation of human K562 cells and cDNA cloning of the human type IIB activin receptor. [Blood. 1994]
Characterization of a 1200-kb genomic segment of chromosome 3p22-p21.3. [DNA Res. 1999]
ReviewMechanisms of inhibin signal transduction. [Recent Prog Horm Res. 2001]
ReviewBone morphogenetic proteins. [Growth Factors. 2004]

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Genomic organization and mapping of the human activin receptor type IIB (hActR-IIB) gene.

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