Sulfoquinovosyldiacylglycerol, KM043, a new potent inhibitor of eukaryotic DNA polymerases and HIV-reverse transcriptase type 1 from a marine red alga, Gigartina tenella

Chem Pharm Bull (Tokyo). 1998 Apr;46(4):684-6. doi: 10.1248/cpb.46.684.

Abstract

A new sulfolipid, KM043, which belongs to the 6-sulfo-alpha-D-quinovopyranosyl-(1-->3')-1',2'-diacylglycerol (SQDG) class of compounds, has been isolated from a marine red alga, Gigartina tenella, as a potent inhibitor of eukaryotic DNA polymerases and HIV-reverse transcriptase type 1. Its structure was determined on the basis of spectroscopic and gas chromatographic analyses. The inhibition was dose-dependent, and complete (more than 90%) inhibition of DNA polymerase alpha (pol. alpha), DNA polymerase beta (pol. beta) and HIV-reverse transcriptase type 1 (HIV-RT) was observed at concentrations of 5, 10, and 30 microM, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromatography, Gas
  • Diglycerides / isolation & purification
  • Glycolipids / chemistry
  • Glycolipids / isolation & purification*
  • HIV Reverse Transcriptase / antagonists & inhibitors*
  • Nucleic Acid Synthesis Inhibitors*
  • Reverse Transcriptase Inhibitors / chemistry
  • Reverse Transcriptase Inhibitors / isolation & purification*
  • Rhodophyta / chemistry*
  • Spectrometry, Mass, Fast Atom Bombardment

Substances

  • Diglycerides
  • Glycolipids
  • Nucleic Acid Synthesis Inhibitors
  • Reverse Transcriptase Inhibitors
  • sulfoquinovosyl diglyceride
  • HIV Reverse Transcriptase