Fomitellic acids, triterpenoid inhibitors of eukaryotic DNA polymerases from a basidiomycete, Fomitella fraxinea

N Tanaka; A Kitamura; Y Mizushina; F Sugawara; K Sakaguchi

doi:10.1021/np970127a

Fomitellic acids, triterpenoid inhibitors of eukaryotic DNA polymerases from a basidiomycete, Fomitella fraxinea

J Nat Prod. 1998 Feb;61(2):193-7. doi: 10.1021/np970127a.

Authors

N Tanaka¹, A Kitamura, Y Mizushina, F Sugawara, K Sakaguchi

Affiliation

¹ Department of Applied Biological Science, Science University of Tokyo, Japan.

PMID: 9514006
DOI: 10.1021/np970127a

Abstract

Four new triterpenoid compounds, 1-4, were isolated from the mycelium of a basidiomycete, Fomitella fraxinea, and their structures determined by spectroscopic analyses. Compounds 1-5 inhibited calf DNA polymerase alpha and rat DNA polymerase beta, with respective minimum inhibitory concentration (MIC) ranges of 35-75 and 90-130 microM.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Basidiomycota / drug effects
Basidiomycota / enzymology*
Chromatography, High Pressure Liquid
Enzyme Inhibitors / isolation & purification*
Enzyme Inhibitors / pharmacology
Magnetic Resonance Spectroscopy
Nucleic Acid Synthesis Inhibitors*
Rats
Triterpenes / isolation & purification*
Triterpenes / pharmacology

Substances

Enzyme Inhibitors
Nucleic Acid Synthesis Inhibitors
Triterpenes