Isolation of a cDNA encoding a widely expressed novel zinc finger protein with the LeR and KRAB-A domains

Biochim Biophys Acta. 1997 Jul 17;1353(1):13-7. doi: 10.1016/s0167-4781(97)00074-2.

Abstract

We have isolated a human cDNA clone representing a novel human gene. The predicted 683-amino-acid protein, designated FPM315, contains nine C2H2-type zinc finger motifs and two regions homologous to the LeR domain, a finger-associated structural domain, and the A element of the Kruppel-associated box (KRAB) domain involved in transcriptional repression. The FPM315 mRNAs were expressed in all human tissues so far examined. A cross-species genomic hybridization indicates that the FPM315 gene is highly conserved among eukaryotes. These data suggest that FPM315 might play an important role in basic cellular processes.

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • DNA, Complementary / genetics
  • DNA, Complementary / isolation & purification*
  • DNA-Binding Proteins / chemistry
  • DNA-Binding Proteins / genetics*
  • Humans
  • Molecular Sequence Data
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • Zinc Fingers*

Substances

  • DNA, Complementary
  • DNA-Binding Proteins
  • RNA, Messenger
  • ZNF263 protein, human

Associated data

  • GENBANK/D88827