Abstract
TRAIL (also called Apo2L) belongs to the tumor necrosis factor family, activates rapid apoptosis in tumor cells, and binds to the death-signaling receptor DR4. Two additional TRAIL receptors were identified. The receptor designated death receptor 5 (DR5) contained a cytoplasmic death domain and induced apoptosis much like DR4. The receptor designated decoy receptor 1 (DcR1) displayed properties of a glycophospholipid-anchored cell surface protein. DcR1 acted as a decoy receptor that inhibited TRAIL signaling. Thus, a cell surface mechanism exists for the regulation of cellular responsiveness to pro-apoptotic stimuli.
MeSH terms
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Amino Acid Sequence
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Apoptosis Regulatory Proteins
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Apoptosis*
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Cell Membrane / metabolism
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Cells, Cultured
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GPI-Linked Proteins
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Glycosylphosphatidylinositols / metabolism
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HeLa Cells
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Humans
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Ligands
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Membrane Glycoproteins / metabolism*
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Molecular Sequence Data
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NF-kappa B / metabolism
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Receptors, TNF-Related Apoptosis-Inducing Ligand
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Receptors, Tumor Necrosis Factor / chemistry
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Receptors, Tumor Necrosis Factor / genetics
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Receptors, Tumor Necrosis Factor / metabolism*
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Receptors, Tumor Necrosis Factor, Member 10c
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Signal Transduction
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TNF-Related Apoptosis-Inducing Ligand
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Transfection
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Tumor Cells, Cultured
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Tumor Necrosis Factor Decoy Receptors
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Tumor Necrosis Factor-alpha / metabolism*
Substances
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Apoptosis Regulatory Proteins
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GPI-Linked Proteins
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Glycosylphosphatidylinositols
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Ligands
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Membrane Glycoproteins
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NF-kappa B
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Receptors, TNF-Related Apoptosis-Inducing Ligand
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Receptors, Tumor Necrosis Factor
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Receptors, Tumor Necrosis Factor, Member 10c
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TNF-Related Apoptosis-Inducing Ligand
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TNFRSF10A protein, human
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TNFRSF10B protein, human
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TNFRSF10C protein, human
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TNFSF10 protein, human
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Tumor Necrosis Factor Decoy Receptors
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Tumor Necrosis Factor-alpha
Associated data
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GENBANK/AF012535
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GENBANK/AF012536