Abstract
The gene apparently responsible for a heritable form of murine pituitary-dependent dwarfism (Ames dwarf, df) has been positionally cloned, identifying a novel, tissue-specific, paired-like homeodomain transcription factor, termed Prophet of Pit-1 (Prop-1). The df phenotype results from an apparent failure of initial determination of the Pit-1 lineage required for production of growth hormone, prolactin or thyroid-stimulating hormone, resulting in dysmorphogenesis and failure to activate Pit-1 gene expression. These results imply that a cascade of tissue-specific regulators is responsible for the determination and differentiation of specific cell lineages in pituitary organogenesis.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Alleles
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Amino Acid Sequence
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Animals
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Cell Lineage
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DNA-Binding Proteins / genetics*
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Dwarfism, Pituitary / embryology
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Dwarfism, Pituitary / genetics*
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Female
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Gene Expression
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Homeodomain Proteins / genetics*
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Homeodomain Proteins / physiology
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Hypothalamus / physiology
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Male
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Mice
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Mice, Inbred C57BL
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Molecular Sequence Data
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Pituitary Gland, Anterior / abnormalities
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Pituitary Gland, Anterior / embryology*
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Pituitary Gland, Anterior / physiology
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Point Mutation
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Sequence Homology, Amino Acid
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Signal Transduction
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Transcription Factor Pit-1
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Transcription Factors / genetics*
Substances
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DNA-Binding Proteins
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Homeodomain Proteins
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Pit1 protein, mouse
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Prophet of Pit-1 protein
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Transcription Factor Pit-1
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Transcription Factors