Specific inhibition of human immunodeficiency virus type 1 reverse transcriptase mediated by soulattrolide, a coumarin isolated from the latex of calophyllum teysmannii

T Pengsuparp; M Serit; S H Hughes; D D Soejarto; J M Pezzuto

doi:10.1021/np960399y

Specific inhibition of human immunodeficiency virus type 1 reverse transcriptase mediated by soulattrolide, a coumarin isolated from the latex of calophyllum teysmannii

J Nat Prod. 1996 Sep;59(9):839-42. doi: 10.1021/np960399y.

Authors

T Pengsuparp¹, M Serit, S H Hughes, D D Soejarto, J M Pezzuto

Affiliation

¹ Department of Biochemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand.

PMID: 8864237
DOI: 10.1021/np960399y

Abstract

Soulattrolide (1), a coumarin isolated from Calophyllum teysmannii latex, was found to be a potent inhibitor of HIV-1 reverse transcriptase (RT) with an IC50 of 0.34 microM. Inhibition was remarkably specific, with no appreciable activity being observed toward HIV-2 RT, AMV RT, RNA polymerase, or DNA polymerases alpha or beta.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Coumarins / isolation & purification*
Coumarins / pharmacology
DNA-Directed RNA Polymerases / antagonists & inhibitors
HIV Reverse Transcriptase / antagonists & inhibitors*
HIV-1 / enzymology*
Humans
Indicators and Reagents
Latex / chemistry
Nucleic Acid Synthesis Inhibitors
Plants, Medicinal / chemistry*
Reverse Transcriptase Inhibitors / isolation & purification
Reverse Transcriptase Inhibitors / pharmacology*
Ribonuclease H / antagonists & inhibitors

Substances

Coumarins
Indicators and Reagents
Latex
Nucleic Acid Synthesis Inhibitors
Reverse Transcriptase Inhibitors
soulattrolide
HIV Reverse Transcriptase
DNA-Directed RNA Polymerases
Ribonuclease H