Mapping of DFNB12, a gene for a non-syndromal autosomal recessive deafness, to chromosome 10q21-22

H Chaib; C Place; N Salem; C Dodé; S Chardenoux; J Weissenbach; E el Zir; J Loiselet; C Petit

doi:10.1093/hmg/5.7.1061

Mapping of DFNB12, a gene for a non-syndromal autosomal recessive deafness, to chromosome 10q21-22

Hum Mol Genet. 1996 Jul;5(7):1061-4. doi: 10.1093/hmg/5.7.1061.

Authors

H Chaib¹, C Place, N Salem, C Dodé, S Chardenoux, J Weissenbach, E el Zir, J Loiselet, C Petit

Affiliation

¹ Unité de Génétique Moléculaire Humaine, URA CNRS 1968, Institut Pasteur, Paris, France.

PMID: 8817348
DOI: 10.1093/hmg/5.7.1061

Abstract

We report here, the localization of a new recessive non-syndromal deafness gene (DFNB12) to 10q21-22 by linkage analysis, of a Sunni family. Affected individuals suffer from congenital profound sensorineural hearing loss. A maximum LOD score of 6.40 (theta = 0.00) was obtained with locus D10S535. Analysis of patients carrying recombinations mapped the gene distal to D10S529 and proximal to D10S532, delineating an interval between 11 and 15 cM. Three deaf mouse mutants Jackson circler (jc), Waltzer (v) and Ames waltzer (av) have been localized to the homologous murine region on chromosome 10. Each of these mouse mutants is a candidate mouse model for the DFNB12-associated hearing impairment.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Child
Child, Preschool
Chromosome Mapping*
Chromosomes, Human, Pair 10 / genetics*
Consanguinity
Female
Genes, Recessive / genetics*
Haplotypes
Hearing Loss, Sensorineural / congenital
Hearing Loss, Sensorineural / genetics*
Hearing Loss, Sensorineural / physiopathology
Humans
Lod Score
Male
Pedigree
Syria