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Endothelial alpha globin is a nitrite reductase.
Keller TCS 4th, Lechauve C, Keller AS, Broseghini-Filho GB, Butcher JT, Askew Page HR, Islam A, Tan ZY, DeLalio LJ, Brooks S, Sharma P, Hong K, Xu W, Padilha AS, Ruddiman CA, Best AK, Macal E, Kim-Shapiro DB, Christ G, Yan Z, Cortese-Krott MM, Ricart K, Patel R, Bender TP, Sonkusare SK, Weiss MJ, Ackerman H, Columbus L, Isakson BE. Keller TCS 4th, et al. Nat Commun. 2022 Oct 27;13(1):6405. doi: 10.1038/s41467-022-34154-3. Nat Commun. 2022. PMID: 36302779 Free PMC article.
Oxygen affinity of hemoglobin regulates O2 consumption, metabolism, and physical activity.
Shirasawa T, Izumizaki M, Suzuki Y, Ishihara A, Shimizu T, Tamaki M, Huang F, Koizumi K, Iwase M, Sakai H, Tsuchida E, Ueshima K, Inoue H, Koseki H, Senda T, Kuriyama T, Homma I. Shirasawa T, et al. J Biol Chem. 2003 Feb 14;278(7):5035-43. doi: 10.1074/jbc.M211110200. Epub 2002 Nov 27. J Biol Chem. 2003. PMID: 12458204 Free article.