Molecular structure and genetic mapping of the mouse gastrin gene

FEBS Lett. 1996 May 20;386(2-3):128-32. doi: 10.1016/0014-5793(96)00430-9.

Abstract

The mouse gastrin gene has three exons totalling 460 bp and a deduced preprogastrin of 101 amino acids. The sequence of murine gastrin-34 is 94% identical to rat gastrin-34 and 76% identical to human gastrin-34. At Arg79, mouse progastrin has a unique cleavage site that might allow species-specific synthesis of gastrin-13. Northern analysis and RT-PCR demonstrated that gastrin gene transcripts are abundant in mouse stomach and duodenum and present at low levels in brain, ovary and pancreas, similar to the pattern described for other mammals. The gastrin gene was mapped to the distal region of mouse chromosome 11.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Chromosome Mapping*
  • DNA, Complementary
  • Gastrins / genetics*
  • Gene Expression
  • Humans
  • Mice
  • Molecular Sequence Data
  • Sequence Homology, Amino Acid
  • Transcription, Genetic

Substances

  • DNA, Complementary
  • Gastrins

Associated data

  • GENBANK/X94758
  • GENBANK/X94759
  • GENBANK/X94760