Abstract
We report here the isolation and characterization of a novel human elongation factor-1 beta (EF-1 beta) gene by cDNA selection from YAC mapping on chromosome 5q12-q14. This gene is specifically transcribed in fetal brain and in skeletal muscle and is characterized by a complete sequence homology with previously described EF-1 beta cDNAs. We also assigned the loci for three other EF-1 beta isoforms, to human chromosomes 2, 15 and X. The multiple chromosomal assignments of EF-1 beta loci demonstrates the genetic heterogeneity of human EF-1 beta peptides.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Base Sequence
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Brain / embryology
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Chromosome Mapping*
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Chromosomes, Artificial, Yeast
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Chromosomes, Human*
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Chromosomes, Human, Pair 15
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Chromosomes, Human, Pair 2
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Chromosomes, Human, Pair 5*
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DNA, Complementary / genetics
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Humans
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In Situ Hybridization
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Molecular Sequence Data
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Muscles / embryology
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Peptide Elongation Factor 1
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Peptide Elongation Factors / genetics*
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Polymerase Chain Reaction
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Sequence Homology, Nucleic Acid
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Tissue Distribution
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Transcription, Genetic
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X Chromosome
Substances
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DNA, Complementary
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Peptide Elongation Factor 1
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Peptide Elongation Factors
Associated data
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GENBANK/D17351
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GENBANK/D17636
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GENBANK/D17637
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GENBANK/D17638
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GENBANK/D17639
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GENBANK/D17640
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GENBANK/D17641
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GENBANK/D17642
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GENBANK/L26404
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GENBANK/X71491