A HeLa-cell-encoded p21 is homologous to transcription elongation factor SII

C H Yeh; A J Shatkin

doi:10.1016/0378-1119(94)90112-0

A HeLa-cell-encoded p21 is homologous to transcription elongation factor SII

Gene. 1994 Jun 10;143(2):285-7. doi: 10.1016/0378-1119(94)90112-0.

Authors

C H Yeh¹, A J Shatkin

Affiliation

¹ Center for Advanced Biotechnology and Medicine, Piscataway, NJ 08854.

PMID: 8206389
DOI: 10.1016/0378-1119(94)90112-0

Abstract

A 1.2-kb cDNA clone isolated from a HeLa cell library contains an open reading frame encoding a new protein (p21) of 21 kDa that is approx. 48% similar to members of the eukaryotic transcription elongation factor SII (TFIIS) family. The deduced amino-acid sequence of p21 indicates that it is hydrophilic, basic and contains nuclear localization signals, as well as multiple consensus phosphorylation sites.

MeSH terms

Amino Acid Sequence
Base Sequence
DNA, Complementary / genetics
DNA-Binding Proteins / chemistry*
DNA-Binding Proteins / genetics
HeLa Cells
Humans
Molecular Sequence Data
Sequence Homology, Amino Acid
Transcription Factors / chemistry*
Transcription Factors / genetics
Transcription Factors, General*
Transcriptional Elongation Factors*

Substances

DNA, Complementary
DNA-Binding Proteins
TCEAL1 protein, human
Transcription Factors
Transcription Factors, General
Transcriptional Elongation Factors
transcription factor S-II

Associated data

GENBANK/M99701
GENBANK/X57198