Characterization of type I receptors for transforming growth factor-beta and activin

Science. 1994 Apr 1;264(5155):101-4. doi: 10.1126/science.8140412.

Abstract

Transforming growth factor-beta (TGF-beta) and activin exert their effects by binding to heteromeric complexes of type I and type II receptors. The type II receptors for TGF-beta and activin are transmembrane serine-threonine kinases; a series of related receptors, denoted activin receptor-like kinase (ALK) 1 to 5, have recently been identified, and ALK-6 is described here. ALK-5 has been shown to be a functional TGF-beta type I receptor. A systematic analysis revealed that most ALKs formed heteromeric complexes with the type II receptors for TGF-beta and activin after overexpression in COS cells; however, among the six ALKs, only ALK-5 was a functional TGF-beta type I receptor for activation of plasminogen activator inhibitor-1, and only ALK-2 and ALK-4 bound activin with high affinity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Activin Receptors
  • Activins
  • Amino Acid Sequence
  • Animals
  • Bone Morphogenetic Protein Receptors, Type I
  • Cell Line
  • Inhibins / metabolism*
  • Ligands
  • Mice
  • Molecular Sequence Data
  • Protein Serine-Threonine Kinases / chemistry
  • Protein Serine-Threonine Kinases / metabolism*
  • Receptors, Growth Factor / chemistry
  • Receptors, Growth Factor / metabolism*
  • Receptors, Transforming Growth Factor beta / chemistry
  • Receptors, Transforming Growth Factor beta / metabolism*
  • Transforming Growth Factor beta / metabolism*

Substances

  • Ligands
  • Receptors, Growth Factor
  • Receptors, Transforming Growth Factor beta
  • Transforming Growth Factor beta
  • Activins
  • Inhibins
  • Protein Serine-Threonine Kinases
  • Activin Receptors
  • BMPR1B protein, human
  • Bmpr1b protein, mouse
  • Bone Morphogenetic Protein Receptors, Type I

Associated data

  • GENBANK/Z23143