The HOX complex neighbored by the EVX gene, as well as two other homeobox-containing genes, the GBX-class and the EN-class, are located on the same chromosomes 2 and 7 in humans

FEBS Lett. 1993 Dec 20;336(1):107-10. doi: 10.1016/0014-5793(93)81620-f.

Abstract

Two newly identified human homeobox-containing genes, GBX1 and GBX2, are closely related genes, as are members of the other homeobox genes, EN-1 and EN-2. GBX1 and EN-2 have been mapped to chromosome 7q36. The present study shows that GBX2 was mapped to chromosome 2q37. EN-1 was mapped to chromosome 2q14. Moreover, two HOX complexes neighbored by the EVX gene, HOXA and HOXD, are located at chromosome 7p15-p14 and 2q31-q37, respectively. Thus, it is possible that these homeobox genes were linked to each other on an ancestral genome and that the ancestral chromosome segment was duplicated during evolution.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Chromosome Mapping
  • Chromosomes, Human, Pair 2*
  • Chromosomes, Human, Pair 7*
  • DNA-Binding Proteins / genetics
  • Genes, Homeobox*
  • Homeodomain Proteins*
  • Humans
  • Molecular Sequence Data
  • Proteins / genetics*
  • Sequence Homology, Amino Acid

Substances

  • DNA-Binding Proteins
  • EN1 protein, human
  • GBX2 protein, human
  • Gbx2 protein, mouse
  • Homeodomain Proteins
  • Proteins

Associated data

  • GENBANK/U02080