Abstract
A gene from human chromosome 11p11.2 was isolated and was shown to suppress metastasis when introduced into rat AT6.1 prostate cancer cells. Expression of this gene, designated KAI1, was reduced in human cell lines derived from metastatic prostate tumors. KAI1 specifies a protein of 267 amino acids, with four hydrophobic and presumably transmembrane domains and one large extracellular hydrophilic domain with three potential N-glycosylation sites. KAI1 is evolutionarily conserved, is expressed in many human tissues, and encodes a member of a structurally distinct family of leukocyte surface glycoproteins. Decreased expression of this gene may be involved in the malignant progression of prostate and other cancers.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Antigens, CD / chemistry
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Antigens, CD / genetics*
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Antigens, CD / physiology
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Base Sequence
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Biological Evolution
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Chromosomes, Human, Pair 11*
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Gene Expression
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Genes, Tumor Suppressor*
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Humans
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Kangai-1 Protein
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Male
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Membrane Glycoproteins / chemistry
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Membrane Glycoproteins / genetics*
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Membrane Glycoproteins / physiology
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Mice
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Mice, SCID
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Molecular Sequence Data
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Neoplasm Metastasis / genetics*
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Prostatic Neoplasms / genetics*
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Prostatic Neoplasms / pathology
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Proto-Oncogene Proteins*
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Rats
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Transfection
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Tumor Cells, Cultured
Substances
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Antigens, CD
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CD82 protein, human
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Cd82 antigen, mouse
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Cd82 protein, rat
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Kangai-1 Protein
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Membrane Glycoproteins
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Proto-Oncogene Proteins