Abstract
The Kit protein is a cell-surface tyrosine kinase receptor encoded by the c-kit proto-oncogene. cDNA clones encoding chicken Kit were isolated from a chicken brain cDNA library, and the nucleotide (nt) sequence of a cDNA clone containing the entire protein-coding region was determined. The deduced amino acid (aa) sequence of chicken Kit shows 63% identity to mouse Kit, and suggests that chicken Kit shares common structural and functional features with mouse Kit. RNA blot analysis indicated that the expression pattern of the chicken c-kit transcript in chicken organs was similar to that of mouse c-kit in mice, suggesting that chicken Kit has biological roles analogous to those of mouse Kit.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Brain Chemistry / genetics
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Chickens / genetics*
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Cloning, Molecular
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Gene Expression
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Male
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Mice
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Molecular Sequence Data
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Protein-Tyrosine Kinases / genetics*
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Proto-Oncogene Proteins / genetics*
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Proto-Oncogene Proteins c-kit
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RNA, Messenger / analysis
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Receptors, Colony-Stimulating Factor / genetics*
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Sequence Homology, Amino Acid
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Testis / chemistry
Substances
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Proto-Oncogene Proteins
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RNA, Messenger
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Receptors, Colony-Stimulating Factor
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Protein-Tyrosine Kinases
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Proto-Oncogene Proteins c-kit
Associated data
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GENBANK/D13225
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GENBANK/D13299
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GENBANK/D13300
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GENBANK/D13301
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GENBANK/D13302
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GENBANK/L03653
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GENBANK/L03654
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GENBANK/L07632
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GENBANK/X54209
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GENBANK/X67926