Abstract
Two forms of a member of the POU domain family of transcriptional regulators, highly related to Oct-2, are selectively expressed in terminally differentiating epidermis and hair follicles. One form, referred to as Skn-1i, contains an amino-terminal domain that inhibits DNA binding and can inhibit transactivation by Oct-1. A second form, Skn-1a, contains an alternative amino terminus and serves to activate cytokeratin 10 (K10) gene expression. The pattern of expression of the Skn-1a/i gene products and the effect of the alternative products on the expression of other genes suggest that these factors serve regulatory functions with respect to epidermal development.
Publication types
-
Comparative Study
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Amino Acid Sequence
-
Animals
-
Base Sequence
-
Basic-Leucine Zipper Transcription Factors
-
DNA / chemistry
-
DNA / genetics
-
DNA / metabolism
-
DNA-Binding Proteins / chemistry
-
DNA-Binding Proteins / genetics*
-
Epidermis / metabolism*
-
Gene Expression* / drug effects
-
Keratins / genetics
-
Leucine Zippers
-
Macromolecular Substances
-
Mice
-
Molecular Sequence Data
-
Nucleic Acid Hybridization
-
Octamer Transcription Factor-2
-
Polymerase Chain Reaction
-
Repressor Proteins*
-
Sequence Homology, Amino Acid
-
Transcription Factors / chemistry
-
Transcription Factors / genetics*
-
Transcription Factors / metabolism
-
Transcription Factors / pharmacology
Substances
-
Basic-Leucine Zipper Transcription Factors
-
DNA-Binding Proteins
-
Macromolecular Substances
-
Octamer Transcription Factor-2
-
Pou2f2 protein, mouse
-
Pou2f2 protein, rat
-
Repressor Proteins
-
TEF protein, human
-
Tef protein, mouse
-
Transcription Factors
-
Keratins
-
DNA
Associated data
-
GENBANK/L23862
-
GENBANK/L23863