Crystal structure of a TFIIB-TBP-TATA-element tern...[Nature. 1995]

SearchDatabase nameforSearch term

Advanced Search

Your browser version may not work well with NCBI's Web applications. More information here...

Display Show

All: 1

Review: 0

Click to change filter selection through MyNCBI.

1: Nature. 1995 Sep 14;377(6545):119-28. Links

Crystal structure of a TFIIB-TBP-TATA-element ternary complex.

Nikolov DB, Chen H, Halay ED, Usheva AA, Hisatake K, Lee DK, Roeder RG, Burley SK.

Laboratories of Molecular Biophysics, Rockefeller University, New York, New York 10021, USA.

The crystal structure of the transcription factor IIB (TFIIB)/TATA box-binding protein (TBP)/TATA-element ternary complex is described at 2.7 A resolution. Core TFIIB resembles cyclin A, and recognizes the preformed TBP-DNA complex through protein-protein and protein-DNA interactions. The amino-terminal domain of core TFIIB forms the downstream surface of the ternary complex, where it could fix the transcription start site. The remaining surfaces of TBP and the TFIIB can interact with TBP-associated factors, other class II initiation factors, and transcriptional activators and coactivators.

PMID: 7675079 [PubMed - indexed for MEDLINE]

ReviewX-ray crystallographic studies of eukaryotic transcription initiation factors. [Philos Trans R Soc Lond B Biol Sci. 1996]
Virtually unidirectional binding of TBP to the AdMLP TATA box within the quaternary complex with TFIIA and TFIIB. [Chem Biol. 2000]
The 2.1-A crystal structure of an archaeal preinitiation complex: TATA-box-binding protein/transcription factor (II)B core/TATA-box. [Proc Natl Acad Sci U S A. 1997]
Topological localization of the human transcription factors IIA, IIB, TATA box-binding protein, and RNA polymerase II-associated protein 30 on a class II promoter. [J Biol Chem. 1994]
ReviewThe TATA box binding protein. [Curr Opin Struct Biol. 1996]

Display Show

Crystal structure of a TFIIB-TBP-TATA-element ternary complex.

Related Articles