The genes for human brain factor 1 and 2, members of the fork head gene family, are clustered on chromosome 14q

Biochim Biophys Acta. 1995 Jun 9;1262(2-3):105-12. doi: 10.1016/0167-4781(95)00059-p.

Abstract

Brain factor-1 (BF-1) is a member of the fork head gene family which shows expression restricted to the neurons of the developing telencephalon in rodents and man. We have isolated a second human gene (HBF-2), which is also strongly expressed in embryonic brain and has very high homology to both the rat and human brain factor-1 genes and the retroviral oncogene qin. The HBF-2 cDNA was isolated from a human fetal brain expression library and contains a putative open reading frame of 479 amino acids. The HBF-2 gene is strongly expressed in fetal brain and also with lower levels of expression in several adult tissues. At the genomic level the gene for HBF-1 contains an 500 bp intron situated between the DNA binding domain II and the fork head domain while that of HBF-2 is intronless. The two genes are clustered on human chromosome 14q11-13.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Chromosomes, Human, Pair 14 / chemistry*
  • DNA-Binding Proteins / genetics*
  • Forkhead Transcription Factors
  • Humans
  • Molecular Sequence Data
  • Multigene Family
  • Nerve Tissue Proteins / genetics*
  • Sequence Alignment
  • Telencephalon / chemistry*

Substances

  • DNA-Binding Proteins
  • FOXG1 protein, human
  • Forkhead Transcription Factors
  • Nerve Tissue Proteins

Associated data

  • GENBANK/X74142
  • GENBANK/X74143
  • GENBANK/X78202