Abstract
Several atomic structures are now available for the family of helical cytokines, which includes growth hormone as well as many of the interleukins. Using structural information from five members of this family, two alternative models of interleukin (IL)-13 are proposed. IL-13 has biological properties similar to those of IL-4 and, like the other interleukins, is a potentially important pharmaceutical target. The model of IL-13 is discussed and compared with the known interleukin structures.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Amino Acid Sequence
-
Animals
-
Binding Sites
-
Disulfides / chemistry
-
Granulocyte Colony-Stimulating Factor / chemistry
-
Granulocyte Colony-Stimulating Factor / genetics
-
Granulocyte-Macrophage Colony-Stimulating Factor / chemistry
-
Granulocyte-Macrophage Colony-Stimulating Factor / genetics
-
Growth Hormone / chemistry
-
Growth Hormone / genetics
-
Humans
-
Interleukin-13 / chemistry*
-
Interleukin-13 / genetics
-
Interleukin-2 / chemistry
-
Interleukin-2 / genetics
-
Interleukin-4 / chemistry
-
Interleukin-4 / genetics
-
Mice
-
Models, Molecular
-
Molecular Sequence Data
-
Protein Conformation
-
Protein Engineering
-
Sequence Homology, Amino Acid
Substances
-
Disulfides
-
Interleukin-13
-
Interleukin-2
-
Granulocyte Colony-Stimulating Factor
-
Interleukin-4
-
Granulocyte-Macrophage Colony-Stimulating Factor
-
Growth Hormone