[Hypervolemic hemodilution as a means of preventing homologous blood transfusion. A simple alternative to acute normovolemic hemodilution]

Fortschr Med. 1994 Oct 20;112(29):410-4.
[Article in German]

Abstract

Problem: Acute normovolenic hemodilution (ANH) is timeconsuming and complicated, and has only a small effect in reducing the need for homologous blood. A simpler procedure is hypervolemic hemodilution (HHD). In the present prospective, randomized study, HHD is compared with ANH for its blood-saving effect.

Study design: Forty-nine patients undergoing total hip replacement were admitted. Group I (ANH): Withdrawal of 15 ml/kg bodyweight autologous blood and isovolemic replacement by hydroxyethyl starch (200/0.5). Group II (HHD): Infusion of 15 ml/kg bodyweight hydroxyethyl starch (200/0.5).

Results: No significant differences were found between the groups in terms of Hb, hematocrit and coagulation. The blood loss (intra-operative+drainage losses) was comparable in the two groups at 1274 +/- 310 ml (HHD) and 130 +/- 335 ml (ANH). During the period under investigation, 66% of the patients in the HHD group and 57% in the ANH group required no homologous blood.

Conclusion: HHD is just as effective as ANH for reducing homologous blood requirements, and is much simpler to apply.

Publication types

  • Clinical Trial
  • Comparative Study
  • English Abstract
  • Randomized Controlled Trial

MeSH terms

  • Blood Loss, Surgical / physiopathology
  • Blood Pressure / physiology
  • Blood Transfusion*
  • Blood Transfusion, Autologous*
  • Blood Volume / physiology*
  • Heart Rate / physiology
  • Hemodilution / methods*
  • Hip Prosthesis*
  • Humans
  • Hydroxyethyl Starch Derivatives / administration & dosage
  • Prospective Studies

Substances

  • Hydroxyethyl Starch Derivatives