The cysteine-rich protein family of highly related LIM domain proteins

J Biol Chem. 1995 Dec 1;270(48):28946-54. doi: 10.1074/jbc.270.48.28946.

Abstract

Here we describe a family of closely related LIM domain proteins in avian cells. The LIM motif defines a zinc-binding domain that is found in a variety of transcriptional regulators, proto-oncogene products, and proteins associated with sites of cell-substratum contact. One type of LIM-domain protein, called the cysteine-rich protein (CRP), is characterized by the presence of two LIM domains linked to short glycine-rich repeats and a potential nuclear localization signal. We have identified and characterized two evolutionarily conserved members of the CRP family, CRP1 and CRP2, in chicken and quail. Expression of the genes encoding both CRP1 and CRP2 is differentially regulated in normal versus transformed cells, raising the possibility that members of the CRP family may function in control of cell growth and differentiation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Avian Proteins*
  • Base Sequence
  • Cell Line
  • Cell Line, Transformed
  • Chick Embryo
  • DNA, Complementary / chemistry
  • Fibroblasts / metabolism
  • Molecular Sequence Data
  • Multigene Family
  • Muscle Proteins / chemistry
  • Muscle Proteins / genetics*
  • Proteins / chemistry
  • Proteins / genetics*
  • Proto-Oncogene Proteins c-myc / chemistry
  • Proto-Oncogene Proteins c-myc / genetics*
  • Quail / embryology
  • Sequence Homology, Amino Acid
  • Sequence Homology, Nucleic Acid

Substances

  • Avian Proteins
  • DNA, Complementary
  • Muscle Proteins
  • Proteins
  • Proto-Oncogene Proteins c-myc
  • cysteine-rich protein, avian

Associated data

  • GENBANK/U57646
  • GENBANK/X84264
  • GENBANK/Z28333