Structure and variation of human alpha 1-antitryps...[Nature. 1982]

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1: Nature. 1982 Jul 22;298(5872):329-34.Links

Structure and variation of human alpha 1-antitrypsin.

Carrell RW, Jeppsson JO, Laurell CB, Brennan SO, Owen MC, Vaughan L, Boswell DR.

The sequence of alpha 1-antitrypsin is in keeping with its role as a tissue scavenger of leukocyte elastase. Two abnormal variants commonly present in Europeans cause a deficiency that predisposes them to a progressive loss of lung elasticity. The nature of the reactive centre helps explain why cigarette smoking greatly accelerates the onset and severity of this degenerative process to give the disease emphysema.

PMID: 7045697 [PubMed - indexed for MEDLINE]

ReviewAlpha1-antitrypsin deficiency (second of two parts). [N Engl J Med. 1978]
ReviewClinical features and molecular characteristics of alpha 1-antitrypsin deficiency. [Ann Allergy. 1994]
A matched-pair study of the leukocyte elastase-like activity in normal persons and in emphysematous patients with and without alpha 1-antitrypsin deficiency. [Am Rev Respir Dis. 1980]
ReviewAlpha 1-antitrypsin deficiency: pathogenesis and treatment. [Hosp Pract (Off Ed). 1991]
ReviewAlpha-1-antitrypsin deficiency and liver disease. [Dig Dis. 1994]

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Structure and variation of human alpha 1-antitrypsin.

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