Abstract
The initial event in the replication cycle of parvovirus H-1 is conversion of the single-stranded linear viral DNA to the double-stranded linear replicative form. We describe here detection of an activity in uninfected cell extracts that carries out this reaction. The activity was purified and identified as DNA polymerase gamma.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Cell Line
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DNA Polymerase III / metabolism*
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DNA Replication*
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DNA, Viral / genetics*
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DNA-Directed DNA Polymerase / metabolism*
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Female
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Humans
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Kidney / embryology
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Molecular Weight
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Parvoviridae / enzymology
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Parvoviridae / genetics*
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Placenta / enzymology
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Pregnancy
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Templates, Genetic
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Virus Replication
Substances
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DNA, Viral
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DNA Polymerase III
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DNA-Directed DNA Polymerase