A major human histone gene cluster on the long arm of chromosome 1

Science. 1984 Nov 16;226(4676):838-40. doi: 10.1126/science.6494913.

Abstract

A human histone gene cluster was assigned to chromosome 1 by Southern blot analysis of DNA's from a series of mouse-human somatic cell hybrids with 32P-labeled cloned human H4 and H3 histone DNA as probes. Localization of this histone gene cluster on the long arm of chromosome 1 was confirmed by in situ hybridization of this DNA probe to metaphase chromosomes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Chromosome Mapping*
  • Chromosomes, Human, 1-3*
  • Chromosomes, Human, 6-12 and X
  • DNA / metabolism
  • Genes
  • Histones / genetics*
  • Humans
  • Hybrid Cells / metabolism
  • Mice
  • Nucleic Acid Hybridization

Substances

  • Histones
  • DNA