Induction of spleen cell growth and DNA polymerase activity by Corynebacterium parvum

Cancer Res. 1978 Jun;38(6):1617-20.

Abstract

Corynebacterium parvum induces rapid proliferation of spleen cells with concomitant rapid increases in DNA synthesis as measured by [3H]thymidine uptake and increase in DNA polymerase activity. Cell number increased exponentially over 10 days. DNA polymerase activity increased 8-fold after C. parvum stimulation. The rapidity of response indicated a population response to the stimulus, and the data are consistent with a direct stimulation of spleen cell proliferation by C. parvum.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cell Count
  • Cell Division
  • DNA / biosynthesis
  • DNA-Directed DNA Polymerase / metabolism*
  • Female
  • Kinetics
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Organ Size
  • Propionibacterium acnes / immunology*
  • Spleen / anatomy & histology
  • Spleen / cytology*
  • Spleen / metabolism

Substances

  • DNA
  • DNA-Directed DNA Polymerase