The human c-Ha-ras2 is a processed pseudogene inactivated by numerous base substitutions

Nucleic Acids Res. 1984 Feb 24;12(4):1821-8. doi: 10.1093/nar/12.4.1821.

Abstract

The human c-Ha-ras2 gene, one of two known members of the Harvey ras family, is reportedly located on the X-chromosome and has lost introns (1, 2). There has heretofore been no information on its precise gene structure and oncogenic potential. We have determined the nucleotide sequence of the c-Ha-ras2 and demonstrate that it is a processed pseudogene surrounded by several direct repeats and contains numerous base substitutions as well as a notable mutation (AGT at codon 12 of the p21 protein) responsible for oncogenic conversion of the known ras genes (3-8).

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Composition
  • Base Sequence
  • Cell Transformation, Neoplastic
  • Cloning, Molecular
  • DNA Transposable Elements
  • Female
  • Genes, Viral*
  • Harvey murine sarcoma virus / genetics*
  • Humans
  • Mutation
  • Oncogenes*
  • Sarcoma Viruses, Murine / genetics*
  • X Chromosome / physiology*

Substances

  • DNA Transposable Elements

Associated data

  • GENBANK/X00419