Partial amino-acid sequences of human and rabbit C...[Proc Natl Acad Sci U S A. 1977]

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1: Proc Natl Acad Sci U S A. 1977 Mar;74(3):1214-8. Links

Partial amino-acid sequences of human and rabbit C-reactive proteins: homology with immunoglobulins and histocompatibility antigens.

Osmand AP, Gerwurz H, Friedenson B.

Partial amino-acid sequence analyses of the amino terminus of rabbit C-reactive protein and of a peptide isolated from human C-reactive protein after cyanogen bromide cleavage show an extensive sequence homology between these proteins. Computer analysis detected a distant but significant homology between rabbit C-reactive protein and the CH3 domain of human IgG, In addition, an examination of the limited data available for the amino-acid sequences of human and mouse histocompatibility antigens revealed a similarity between these proteins and C-reactive protein and, therefore, immunoglobulins; These relationships are presented as evidence in support of the hypothesis that C-reactive protein and immunoglobulins share, in addition to functional similarities, a common evolutionary origin with the major histocompatibility antigens.

PMID: 403526 [PubMed - indexed for MEDLINE]

PMCID: PMC430653

Primary structure of human C-reactive protein. [J Biol Chem. 1979]
An evaluation of the significance of amino acid sequence homologies in human histocompatibility antigens (HLA-A and HLA-B) with immunoglobulins and other proteins, using relatively short sequences. [Scand J Immunol. 1980]
Characterization of C-reactive protein and the complement subcomponent C1t as homologous proteins displaying cyclic pentameric symmetry (pentraxins). [Proc Natl Acad Sci U S A. 1977]
ReviewShared antigenic determinants of immunoglobulins in phylogeny and in comparison with T-cell receptors. [Comp Biochem Physiol B. 1993]
ReviewA comparison of the amino acid sequences of the extracellular domains of the immunoglobulin superfamily. Possible correlations between conservancy and conformation. [Comp Biochem Physiol B. 1985]

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Partial amino-acid sequences of human and rabbit C-reactive proteins: homology with immunoglobulins and histocompatibility antigens.

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