Pulling rank with RNA: RANKL promotes the association of PGC-1β/RNA complexes with NCoR/HDAC3 to activate gene expression in osteoclasts

Haydee M Torres; Dongwook Yeo; Jennifer J Westendorf

doi:10.1016/j.molcel.2023.09.012

Pulling rank with RNA: RANKL promotes the association of PGC-1β/RNA complexes with NCoR/HDAC3 to activate gene expression in osteoclasts

Mol Cell. 2023 Oct 5;83(19):3397-3399. doi: 10.1016/j.molcel.2023.09.012.

Authors

Haydee M Torres¹, Dongwook Yeo¹, Jennifer J Westendorf²

Affiliations

¹ Departments of Orthopedic Surgery and Biochemistry and Molecular Biology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
² Departments of Orthopedic Surgery and Biochemistry and Molecular Biology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. Electronic address: westendorf.jennifer@mayo.edu.

Abstract

In this issue, Abe et al¹ report a novel mechanism by which RANKL stimulates osteoclast differentiation and bone resorption through non-coding RNAs that bind PGC-1β and convert the NCoR/HDAC3 co-repressor complex into a co-activator of AP-1- and NFκB-regulated genes.

MeSH terms

Bone Resorption* / metabolism
Cell Differentiation
Gene Expression
Humans
NF-kappa B / metabolism
Osteoclasts* / metabolism
RANK Ligand / genetics
RANK Ligand / metabolism
RNA / metabolism

Substances

RNA
NF-kappa B
RANK Ligand

Abstract

MeSH terms

Substances

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