A review on the role of GHET1 in different cancers

Soudeh Ghafouri-Fard; Sara Ahmadi Teshnizi; Bashdar Mahmud Hussen; Mohammad Taheri; Hakimeh Zali

doi:10.1016/j.prp.2023.154545

A review on the role of GHET1 in different cancers

Pathol Res Pract. 2023 Jul:247:154545. doi: 10.1016/j.prp.2023.154545. Epub 2023 May 17.

Authors

Soudeh Ghafouri-Fard¹, Sara Ahmadi Teshnizi², Bashdar Mahmud Hussen³, Mohammad Taheri⁴, Hakimeh Zali⁵

Affiliations

¹ Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
² Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
³ Department of Clinical Analysis, College of Pharmacy, Hawler Medical University, Kurdistan Region, Erbil, Iraq.
⁴ Institute of Human Genetics, Jena University Hospital, Jena, Germany; Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: Mohammad.taheri@uni-jena.de.
⁵ Proteomics Research Center, Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: h.zali@sbmu.ac.ir.

PMID: 37244053
DOI: 10.1016/j.prp.2023.154545

Abstract

Gastric cancer High Expressed Transcript 1 (GHET1) is an RNA gene located on chromosome 7q36.1. This non-coding RNA is involved in the pathology of different cancers. It can regulate cell proliferation, apoptosis and cell cycle transition. Moreover, it induces epithelial-mesenchymal transition. Up-regulation of GHET1 has been correlated with poor prognosis of patients with different malignancies. Besides, its up-regulation has been mostly detected in later stages and advanced grades of cancers. This review summarizes recent studies on the expression of GHET1, its in vitro functions, and its impact on the beginning and progression of cancer based on xenograft models of cancer.

Keywords: Biomarker; Cancer; Expression; GHET1; LncRNA.

Publication types

Review

MeSH terms

Biomarkers, Tumor / genetics
Cell Cycle
Cell Line, Tumor
Cell Movement
Cell Proliferation
Epithelial-Mesenchymal Transition
Gene Expression Regulation, Neoplastic
Humans
Neoplasms* / genetics
Prognosis
RNA, Long Noncoding* / genetics

Substances

Biomarkers, Tumor
RNA, Long Noncoding
GHET1 transcript, human