Chromosomal assignment of the gene encoding the human tissue inhibitor of metalloproteinases to Xp11.1-p11.4

N K Spurr; P N Goodfellow; A J Docherty

doi:10.1111/j.1469-1809.1987.tb00870.x

Chromosomal assignment of the gene encoding the human tissue inhibitor of metalloproteinases to Xp11.1-p11.4

Ann Hum Genet. 1987 Jul;51(3):189-94. doi: 10.1111/j.1469-1809.1987.tb00870.x.

Authors

N K Spurr¹, P N Goodfellow, A J Docherty

Affiliation

¹ Human Genetic Resources Laboratory, Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms, Herts.

PMID: 3688834
DOI: 10.1111/j.1469-1809.1987.tb00870.x

Abstract

The tissue inhibitor of metalloproteinases (TIMP) is thought to play a regulatory role in connective tissues by forming inactive complexes with those metalloproteinases that are normally responsible for connective tissue turnover. The human gene encoding TIMP has been mapped to the X chromosome in the region Xp11.1-p11.4.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antifibrinolytic Agents*
Chromosome Mapping*
DNA
Genes*
Humans
Hybrid Cells
Metalloendopeptidases / antagonists & inhibitors*
Nucleic Acid Hybridization
Translocation, Genetic
X Chromosome*

Substances

Antifibrinolytic Agents
DNA
Metalloendopeptidases