A review on the role of miR-210 in human disorders

Pathol Res Pract. 2023 Jan:241:154244. doi: 10.1016/j.prp.2022.154244. Epub 2022 Nov 24.

Abstract

MicroRNA-210 (miR-210) is a miRNA with imperative effects in the pathophysiology of human disorders. miR-210 is encoded by MIR210 gene on chromosome 11p15.5. The stem-loop of this miRNA resides in an intron of the AK123483 noncoding RNA. This miRNA is a major hypoxamir whose expression is increased in hypoxic condition in several types of cells. miR-210 has been shown to be up-regulated in almost all types of examined cancer types, except for bladder cancer, angiosarcoma and glioblastoma. Dysregulation of miR-210 in colorectal carcinoma, gastric cancer, head and neck squamous cell carcinoma, pediatric acute lymphoblastic leukemia, glioblastoma and laryngeal carcinoma has been related with poor clinical outcomes. In the current review, we provide a comprehensive summary of participation of miR-210 in human disorders.

Keywords: Biomarkers; Cancer; MiR-210; MicroRNAs; Noncoding RNA.

Publication types

  • Review

MeSH terms

  • Carcinoma, Squamous Cell* / pathology
  • Cell Line, Tumor
  • Child
  • Gene Expression Regulation, Neoplastic
  • Glioblastoma* / genetics
  • Head and Neck Neoplasms* / genetics
  • Humans
  • MicroRNAs* / metabolism
  • Squamous Cell Carcinoma of Head and Neck / genetics

Substances

  • MicroRNAs
  • MIRN210 microRNA, human