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Phosphorylation at Ser724 of the ER stress sensor IRE1α governs its activation state and limits ER stress-induced hepatosteatosis.
J Biol Chem. 2022 Jun;298(6):101997. doi: 10.1016/j.jbc.2022.101997. Epub 2022 Apr 29.
J Biol Chem. 2022.
PMID: 35500653
Free PMC article.
Phosphorylation of IRE1 at S729 regulates RIDD in B cells and antibody production after immunization.
Tang CH, Chang S, Paton AW, Paton JC, Gabrilovich DI, Ploegh HL, Del Valle JR, Hu CC.
Tang CH, et al.
J Cell Biol. 2018 May 7;217(5):1739-1755. doi: 10.1083/jcb.201709137. Epub 2018 Mar 6.
J Cell Biol. 2018.
PMID: 29511123
Free PMC article.
Item in Clipboard
Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability.
Iwawaki T, Akai R, Yamanaka S, Kohno K.
Iwawaki T, et al.
Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16657-62. doi: 10.1073/pnas.0903775106. Epub 2009 Sep 15.
Proc Natl Acad Sci U S A. 2009.
PMID: 19805353
Free PMC article.
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Hepatic IRE1α regulates fasting-induced metabolic adaptive programs through the XBP1s-PPARα axis signalling.
Shao M, Shan B, Liu Y, Deng Y, Yan C, Wu Y, Mao T, Qiu Y, Zhou Y, Jiang S, Jia W, Li J, Li J, Rui L, Yang L, Liu Y.
Shao M, et al.
Nat Commun. 2014 Mar 27;5:3528. doi: 10.1038/ncomms4528.
Nat Commun. 2014.
PMID: 24670948
Free article.
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The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosis.
Zhang K, Wang S, Malhotra J, Hassler JR, Back SH, Wang G, Chang L, Xu W, Miao H, Leonardi R, Chen YE, Jackowski S, Kaufman RJ.
Zhang K, et al.
EMBO J. 2011 Apr 6;30(7):1357-75. doi: 10.1038/emboj.2011.52. Epub 2011 Mar 15.
EMBO J. 2011.
PMID: 21407177
Free PMC article.
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Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1.
Urano F, Wang X, Bertolotti A, Zhang Y, Chung P, Harding HP, Ron D.
Urano F, et al.
Science. 2000 Jan 28;287(5453):664-6. doi: 10.1126/science.287.5453.664.
Science. 2000.
PMID: 10650002
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IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response.
Lee K, Tirasophon W, Shen X, Michalak M, Prywes R, Okada T, Yoshida H, Mori K, Kaufman RJ.
Lee K, et al.
Genes Dev. 2002 Feb 15;16(4):452-66. doi: 10.1101/gad.964702.
Genes Dev. 2002.
PMID: 11850408
Free PMC article.
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