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Deletion of hypoxia-inducible factor prolyl 4-hydroxylase 2 in FoxD1-lineage mesenchymal cells leads to congenital truncal alopecia.
J Biol Chem. 2022 Apr;298(4):101787. doi: 10.1016/j.jbc.2022.101787. Epub 2022 Mar 2.
J Biol Chem. 2022.
PMID: 35247391
Free PMC article.
Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2.
Takeda K, Ho VC, Takeda H, Duan LJ, Nagy A, Fong GH.
Takeda K, et al.
Mol Cell Biol. 2006 Nov;26(22):8336-46. doi: 10.1128/MCB.00425-06. Epub 2006 Sep 11.
Mol Cell Biol. 2006.
PMID: 16966370
Free PMC article.
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Cardiomyocyte-specific prolyl-4-hydroxylase domain 2 knock out protects from acute myocardial ischemic injury.
Hölscher M, Silter M, Krull S, von Ahlen M, Hesse A, Schwartz P, Wielockx B, Breier G, Katschinski DM, Zieseniss A.
Hölscher M, et al.
J Biol Chem. 2011 Apr 1;286(13):11185-94. doi: 10.1074/jbc.M110.186809. Epub 2011 Jan 26.
J Biol Chem. 2011.
PMID: 21270129
Free PMC article.
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Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization.
Mazzone M, Dettori D, de Oliveira RL, Loges S, Schmidt T, Jonckx B, Tian YM, Lanahan AA, Pollard P, de Almodovar CR, De Smet F, Vinckier S, Aragonés J, Debackere K, Luttun A, Wyns S, Jordan B, Pisacane A, Gallez B, Lampugnani MG, Dejana E, Simons M, Ratcliffe P, Maxwell P, Carmeliet P.
Mazzone M, et al.
Cell. 2009 Mar 6;136(5):839-851. doi: 10.1016/j.cell.2009.01.020. Epub 2009 Feb 12.
Cell. 2009.
PMID: 19217150
Free PMC article.
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Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure.
Minamishima YA, Moslehi J, Bardeesy N, Cullen D, Bronson RT, Kaelin WG Jr.
Minamishima YA, et al.
Blood. 2008 Mar 15;111(6):3236-44. doi: 10.1182/blood-2007-10-117812. Epub 2007 Dec 20.
Blood. 2008.
PMID: 18096761
Free PMC article.
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A knock-in mouse model of human PHD2 gene-associated erythrocytosis establishes a haploinsufficiency mechanism.
Arsenault PR, Pei F, Lee R, Kerestes H, Percy MJ, Keith B, Simon MC, Lappin TRJ, Khurana TS, Lee FS.
Arsenault PR, et al.
J Biol Chem. 2013 Nov 22;288(47):33571-33584. doi: 10.1074/jbc.M113.482364. Epub 2013 Oct 11.
J Biol Chem. 2013.
PMID: 24121508
Free PMC article.
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