Analysis of SIRT4 gene single-nucleotide polymorphisms in a Han Chinese population with dilated cardiomyopathy

Biomark Med. 2022 Jan;16(1):11-21. doi: 10.2217/bmm-2021-0363. Epub 2021 Dec 3.

Abstract

Aim: We aimed to investigate the association of SIRT4 gene polymorphisms with the susceptibility and prognosis of dilated cardiomyopathy (DCM) in a Chinese population. Materials & methods: A total of 369 controls and 373 DCM patients were enrolled. Three tag single-nucleotide polymorphisms (rs2261612, rs2522138 and rs16950058) on SIRT4 were evaluated. Results: G carriers of rs2261612 were associated with the susceptibility of DCM in codominant, dominant and overdominant genetic models (all p < 0.01). Furthermore, the AG/GG and AG genotype of rs2261612 in dominant and overdominant models correlated with poor prognosis of DCM, independent of left ventricular ejection fraction and cardiac resynchronization therapy (p < 0.001). Conclusion:SIRT4 polymorphisms were associated with the susceptibility and prognosis of DCM in a Chinese population.

Keywords: SIRT4; dilated cardiomyopathy; polymorphism; survival analysis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Cardiomyopathy, Dilated / genetics*
  • Cardiomyopathy, Dilated / physiopathology
  • China
  • Ethnicity / genetics*
  • Female
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Mitochondria, Heart / physiology
  • Mitochondrial Proteins / genetics*
  • Polymorphism, Single Nucleotide*
  • Sirtuins / genetics*
  • Ventricular Function, Left

Substances

  • Mitochondrial Proteins
  • SIRT4 protein, human
  • Sirtuins