Association of CYBA C242T and superoxide dismutase 2 A16V genetic variants with preeclampsia

Objective: To investigate the relationship between NADPH oxidase p22phox subunit (CYBA; C242T) and superoxide dismutase 2 (SOD2; A16V) polymorphisms and the risk of preeclampsia (PE) in Chinese women.

Methods: This case-control study included 325 patients with PE and 1294 controls. The genotypes were determined by polymerase chain reaction-restriction fragments length polymorphism method. Clinical, metabolic, and oxidative stress parameters were analyzed.

Results: Participants with T allele of the CYBA C242T polymorphism had a decreased risk of PE (OR = 0.62, 95% CI: 0.42-0.92, P = 0.016) and those with the A allele of the SOD2 A16V polymorphism had increased risk of PE (OR = 1.44, 95% CI: 1.09-1.89, P = 0.010). The coexistence of the SOD2 AA + AV genotypes and the CYBA CC genotype further increased the risk of PE (OR = 2.32, 95% CI: 1.31-4.10, P = 0.003) when the CT + TT/VV combined genotype was the reference category.

Conclusion: The T allele of the CYBA C242T polymorphism is related to a decreased risk of PE, while the A allele of the SOD2 A16V polymorphism and its combination with the CYBA CC genotype are associated with an increased risk of PE in Chinese women.