MG149 inhibits histone acetyltransferase KAT8-mediated IL-33 acetylation to alleviate allergic airway inflammation and airway hyperresponsiveness

Signal Transduct Target Ther. 2021 Sep 8;6(1):321. doi: 10.1038/s41392-021-00667-4.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylation / drug effects
  • Animals
  • Asthma / drug therapy
  • Asthma / metabolism*
  • Histone Acetyltransferases / antagonists & inhibitors*
  • Histone Acetyltransferases / metabolism
  • Inflammation / drug therapy
  • Inflammation / metabolism
  • Interleukin-33 / metabolism*
  • Mice
  • Salicylates / pharmacology*

Substances

  • 2-(2-(4-heptylphenyl)ethyl)-6-hydroxy-benzoic acid
  • Il33 protein, mouse
  • Interleukin-33
  • Salicylates
  • Histone Acetyltransferases
  • Kat8 protein, mouse