Effects of the Xenopus laevis mitochondrial single-stranded DNA-binding protein on the activity of DNA polymerase gamma

B Mignotte; J Marsault; M Barat-Gueride

doi:10.1111/j.1432-1033.1988.tb14123.x

Effects of the Xenopus laevis mitochondrial single-stranded DNA-binding protein on the activity of DNA polymerase gamma

Eur J Biochem. 1988 Jun 15;174(3):479-84. doi: 10.1111/j.1432-1033.1988.tb14123.x.

Authors

B Mignotte¹, J Marsault, M Barat-Gueride

Affiliation

¹ Laboratoire de Biologie Générale, Université de Paris-Sud, Orsay, France.

PMID: 3391165
DOI: 10.1111/j.1432-1033.1988.tb14123.x

Abstract

The single-stranded DNA-binding protein from Xenopus laevis oocyte mitochondria, which has been found associated with the D loop, binds to ssDNA in stoichiometric amounts and can under certain conditions stimulate the activity of the DNA polymerase gamma. Its properties suggest that it is involved in strand displacement during the replication of the mitochondrial genome.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Binding Sites
Binding, Competitive
DNA Polymerase III / metabolism*
DNA Replication
DNA, Single-Stranded / pharmacology*
DNA-Binding Proteins / pharmacology*
DNA-Directed DNA Polymerase / metabolism*
Enzyme Activation / drug effects
Mitochondria / enzymology*
Mitochondria / metabolism
Templates, Genetic
Xenopus / metabolism*

Substances

DNA, Single-Stranded
DNA-Binding Proteins
DNA Polymerase III
DNA-Directed DNA Polymerase