The AKT1 proto-oncogene maps to human chromosome 14, band q32

S P Staal; K Huebner; C M Croce; N Z Parsa; J R Testa

doi:10.1016/0888-7543(88)90114-0

The AKT1 proto-oncogene maps to human chromosome 14, band q32

Genomics. 1988 Jan;2(1):96-8. doi: 10.1016/0888-7543(88)90114-0.

Authors

S P Staal¹, K Huebner, C M Croce, N Z Parsa, J R Testa

Affiliation

¹ Johns Hopkins Oncology Center, John Hopkins University School of Medicine, Baltimore, Maryland 21205.

PMID: 3384441
DOI: 10.1016/0888-7543(88)90114-0

Abstract

The human AKT1 gene is the proto-oncogene of the viral oncogene v-akt. The AKT1 gene has been localized to human chromosome 14, band q32, proximal to the heavy-chain immunoglobulin locus (IGHM), by analysis of human-hamster somatic cell hybrids and by in situ hybridization. Chromosome rearrangements of this band which occur in T-lymphoid malignancies and Hodgkin's disease may affect the AKT1 gene.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Chromosome Mapping
Chromosomes, Human, Pair 14*
Humans
Hybrid Cells / cytology
Karyotyping
Proto-Oncogene Mas
Proto-Oncogenes*
Retroviridae / genetics*