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Two independent mouse lines carrying the Nav1.7 I228M gain-of-function variant display dorsal root ganglion neuron hyperexcitability but a minimal pain phenotype.
Pain. 2021 Jun 1;162(6):1758-1770. doi: 10.1097/j.pain.0000000000002171.
Pain. 2021.
PMID: 33323889
Free PMC article.
Selective optogenetic activation of NaV1.7-expressing afferents in NaV1.7-ChR2 mice induces nocifensive behavior without affecting responses to mechanical and thermal stimuli.
Maruta T, Hidaka K, Kouroki S, Koshida T, Kurogi M, Kage Y, Mizuno S, Shirasaka T, Yanagita T, Takahashi S, Takeya R, Tsuneyoshi I.
Maruta T, et al.
PLoS One. 2022 Oct 6;17(10):e0275751. doi: 10.1371/journal.pone.0275751. eCollection 2022.
PLoS One. 2022.
PMID: 36201719
Free PMC article.
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