Human ros1 and mas1 oncogenes located in regions of chromosome 6 associated with tumor-specific rearrangements

Oncogene Res. 1987 Jul;1(2):169-78.

Abstract

Oncogenes have been implicated in tumorigenesis based on their localization to chromosomal sites associated with tumor-specific structural rearrangements. We have mapped the human ros1 (formerly mcf3) and mas1 oncogenes to the distal half of chromosome 6q, within a region frequently rearranged in malignant cells. Chromosomal mapping of these two new human transforming genes may help elucidate the involvement of the long arm of chromosome 6 in diverse tumor types.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Cell Line
  • Chromosome Mapping
  • Chromosomes, Human, Pair 6*
  • Genes, ras*
  • Humans
  • Leukemia / genetics
  • Neoplasms / genetics
  • Nucleic Acid Hybridization
  • Oncogenes*
  • Proto-Oncogene Mas