Common Variable Immunodeficiency: Epidemiology, Pathogenesis, Clinical Manifestations, Diagnosis, Classification, and Management

J Investig Allergol Clin Immunol. 2020;30(1):14-34. doi: 10.18176/jiaci.0388. Epub 2019 Feb 11.

Abstract

Common variable immunodeficiency (CVID) is a heterogeneous disorder characterized by hypogammaglobulinemia and increased susceptibility to recurrent bacterial infections. It is the most frequent symptomatic antibody deficiency, with a wide variety of infectious and noninfectious complications. Numerous studies have demonstrated that immunological and genetic defects are involved in the pathogenesis of CVID. However, in most cases, the genetic background of the disease remains unidentified. This review aims to discuss various aspects of CVID, including epidemiology, pathogenesis, symptoms, diagnosis, classification, and management.

Keywords: Classifications; Common variable immunodeficiency; Diagnosis; Epidemiology; Management; Pathogenesis; Symptoms.

Publication types

  • Review

MeSH terms

  • Agammaglobulinemia
  • Animals
  • Common Variable Immunodeficiency / diagnosis
  • Common Variable Immunodeficiency / epidemiology*
  • Common Variable Immunodeficiency / therapy
  • Gene-Environment Interaction
  • Hematopoietic Stem Cell Transplantation
  • Humans
  • Immunoglobulins, Intravenous / therapeutic use*
  • Phenotype

Substances

  • Immunoglobulins, Intravenous