High miR-139-3p expression predicts a better prognosis for hepatocellular carcinoma: a pooled analysis

J Int Med Res. 2019 Jan;47(1):383-390. doi: 10.1177/0300060518802727. Epub 2018 Nov 5.

Abstract

Objective: To observe the expression and clinical significance of micro RNA (miR)-139-3p in liver cancer tissues, and to explore its relationship with miR-139-3p target genes related to the prognosis of hepatocellular carcinoma (HCC).

Methods: A total of 362 patients with HCC were included in the study. Liver hepatocellular carcinoma data were obtained directly from The Cancer Genome Atlas data portal .The bioinformatics analysis tool TargetScan was applied to predict miR-139-3p target genes.

Results: Survival time was significantly higher in patients with high miR-139-3p expression, compared with the low miR-139-3p expression group. Bioinformatics analysis showed that miR-139-3p target genes ISG20L2, RAD54B, KIAA0101, and PIGS were significantly negatively correlated with miR-139-3p expression.

Conclusions: High miR-139-3p expression in HCC tissues was indicative of good patient prognosis. miR-139-3p target genes ISG20L2, RAD54B, KIAA0101, and PIGS were related to HCC prognosis.

Keywords: The Cancer Genome Atlas; bioinformatics; hepatocellular carcinoma; miR-139-3p; prognosis; target genes.

MeSH terms

  • Acyltransferases / genetics
  • Acyltransferases / metabolism
  • Aged
  • Atlases as Topic
  • Biomarkers, Tumor / genetics*
  • Biomarkers, Tumor / metabolism
  • Carcinoma, Hepatocellular / diagnosis
  • Carcinoma, Hepatocellular / genetics*
  • Carcinoma, Hepatocellular / mortality
  • Carcinoma, Hepatocellular / pathology
  • Carrier Proteins / genetics
  • Carrier Proteins / metabolism
  • Computational Biology / methods
  • DNA Helicases / genetics*
  • DNA Helicases / metabolism
  • DNA-Binding Proteins
  • Databases, Genetic
  • Exodeoxyribonucleases / genetics*
  • Exodeoxyribonucleases / metabolism
  • Female
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Liver Neoplasms / diagnosis
  • Liver Neoplasms / genetics*
  • Liver Neoplasms / mortality
  • Liver Neoplasms / pathology
  • Male
  • MicroRNAs / genetics*
  • MicroRNAs / metabolism
  • Middle Aged
  • Neoplasm Staging
  • Nuclear Proteins / genetics*
  • Nuclear Proteins / metabolism
  • Prognosis
  • Survival Analysis

Substances

  • Biomarkers, Tumor
  • Carrier Proteins
  • DNA-Binding Proteins
  • MIRN139 microRNA, human
  • MicroRNAs
  • Nuclear Proteins
  • PCLAF protein, human
  • RAD54B protein, human
  • Acyltransferases
  • COOH-terminal signal transamidase
  • AEN protein, human
  • Exodeoxyribonucleases
  • DNA Helicases